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Structure-Based Design, Synthesis, and Biological Evaluation of Novel Inhibitors of Human Cyclophilin A

✍ Scribed by Guichou, Jean-François; Viaud, Julien; Mettling, Clément; Subra, Guy; Lin, Yea-Lih; Chavanieu, Alain


Book ID
118159370
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
389 KB
Volume
49
Category
Article
ISSN
0022-2623

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A series of chloro-pyridazine piperazines were developed based on the structure of human rhinovirus (HRV) capsid-binding inhibitors with proven activity using a pharmacophore model. A preliminary evaluation demonstrated potent activity against HRV-3 with low cytotoxicity. A docking analysis indicate