Structure-Based Design, Synthesis, and Biological Evaluation of Novel 1,4-Diazepines as HDM2 Antagonists.

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of α4β1 Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold

✍ Jürgen Boer; Dirk Gottschling; Anja Schuster; Bernhard Holzmann; Horst Kessler 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of α4β1 Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold

✍ Jürgen Boer; Dirk Gottschling; Anja Schuster; Bernhard Holzmann; Horst Kessler 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of Indole Derivatives as Novel Nociceptin/Orphanin FQ (N/OFQ) Receptor Antagonists.

✍ Yuichi Sugimoto; Atsushi Shimizu; Tetsuya Kato; Atsushi Satoh; Satoshi Ozaki; Hi 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

1,2,4-Triazolo[1,5-a]quinoxaline Derivat

1,2,4-Triazolo[1,5-a]quinoxaline Derivatives: Synthesis and Biological Evaluation as Adenosine Receptor Antagonists.

✍ Daniela Catarzi; Vittoria Colotta; Flavia Varano; Guido Filacchioni; Claudia Mar 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 129 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.

Rational Design, Synthesis, Biological E

Rational Design, Synthesis, Biological Evaluation, Homology and Docking Studies of Coumarin Derivatives as α1-Adrenoceptor Antagonists

✍ Xiang Zhou; Ya-Dong Chen; Tao Wang; Xiao-Bing Wang; Ling-Yi Kong 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of 1,5-Diaryl-1,2,4-triazole Derivatives as Selective Cyclooxygenase-2 Inhibitors

✍ Bo Jiang; Yi Zeng; Meng-Jie Li; Jin-Yi Xu; Yong-Na Zhang; Qiu-Juan Wang; Ni-Yue 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB 👁 1 views