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Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2‘ ‘ Ether Analogues of Paromomycin

✍ Scribed by Hanessian, Stephen; Szychowski, Janek; Adhikari, Susanta Sekhar; Vasquez, Guillermo; Kandasamy, Pachamuthu; Swayze, Eric E.; Migawa, Michael T.; Ranken, Ray; François, Boris; Wirmer-Bartoschek, Julia; Kondo, Jiro; Westhof, Eric

Book ID: 125953050
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 570 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm061200+

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Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

✍ Stephen Hanessian; Kandasamy Pachamuthu; Janek Szychowski; Alexandre Giguère; Er 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 461 KB

Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2 00 of N1-(HABA)-3 0 ,4 0 -dideoxyparomomycin led to a novel analog with an excellent antibacterial profile against a host of resistant bacteria.