✦ LIBER ✦

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

✍ Scribed by Stephen Hanessian; Kandasamy Pachamuthu; Janek Szychowski; Alexandre Giguère; Eric E. Swayze; Michael T. Migawa; Boris François; Jiro Kondo; Eric Westhof

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 461 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.09.084

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✦ Synopsis

Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2 00 of N1-(HABA)-3 0 ,4 0 -dideoxyparomomycin led to a novel analog with an excellent antibacterial profile against a host of resistant bacteria.