𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure-based design of potent CDK1 inhibitors derived from olomoucine

✍ Scribed by Pascal Furet; Juerg Zimmermann; Hans-Georg Capraro; Thomas Meyer; Patricia Imbach


Book ID
110258766
Publisher
Springer Netherlands
Year
2000
Tongue
English
Weight
124 KB
Volume
14
Category
Article
ISSN
0920-654X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Structure-based optimization of potent P
✍ Mauro Angiolini; Patrizia Banfi; Elena Casale; Francesco Casuscelli; Claudio Fio πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 647 KB

In this Letter is described the structure-based design of potent dihydro-pyrazoloquinazolines as PDK1 inhibitors. Starting from low potency HTS hits with the aid of X-ray crystallography and modeling, a medicinal chemistry activity was carried out to improve potency versus PDK1 and selectivity versu