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Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor

✍ Scribed by Shojiro Kadono; Akihisa Sakamoto; Yasufumi Kikuchi; Masayoshi Oh-eda; Naohiro Yabuta; Kazutaka Yoshihashi; Takehisa Kitazawa; Tsukasa Suzuki; Takaki Koga; Kunihiro Hattori; Takuya Shiraishi; Masayuki Haramura; Hirofumi Kodama; Yoshiyuki Ono; Toru Esaki; Haruhiko Sato; Yoshiaki Watanabe; Susumu Itoh; Masateru Ohta; Toshiro Kozono


Book ID
116289738
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
718 KB
Volume
327
Category
Article
ISSN
0006-291X

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## Abstract Dysregulated angiogenesis is implicated in several pathologies, including cancer and age‐related macular degeneration. A potential antiangiogenic strategy consists in developing VEGF receptor ligands capable of preventing VEGF binding and the subsequent activation of these receptors. He