Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors
โ Scribed by Terrence R. Burke Jr.; Zhu-Jun Yao; Ding-Guo Liu; Johannes Voigt; Yang Gao
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2001
- Tongue
- English
- Weight
- 922 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0006-3525
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## Abstract A series of novel nonpeptide inhibitors of the pp60^cโSrc^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an xโray structure of citrate complexed to the pTyr binding site of the Src SH2 do