✦ LIBER ✦

Structure-Based Design of Inhibitors Specific for Bacterial Thymidylate Synthase †,‡

✍ Scribed by Stout, Thomas J.; Tondi, Donatella; Rinaldi, Marcella; Barlocco, Daniela; Pecorari, P.; Santi, Daniel V.; Kuntz, Irwin D.; Stroud, Robert M.; Shoichet, Brian K.; Costi, M. Paola

Book ID: 126948342
Publisher: American Chemical Society
Year: 1999
Tongue: English
Weight: 672 KB
Volume: 38
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi9815896

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structure-Based Design of Lipophilic Qui

Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase

✍ Jones, Terence R.; Varney, Michael D.; Webber, Stephen E.; Lewis, Kathleen K.; M 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 428 KB

ChemInform Abstract: Structure-Based Des

ChemInform Abstract: Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase (TS).

✍ T. R. JONES; M. D. VARNEY; S. E. WEBBER; K. K. LEWIS; G. P. MARZONI; C. L. PALME 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB

Thymidylate synthase inhibition: A struc

Thymidylate synthase inhibition: A structure-based rationale for drug design

✍ M. Paola Costi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB 👁 2 views

Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition causes thimineless death of the cells and compounds inhibiting TS are widely used in anticancer therapy. The classical antifolate TS inhibitors are structural analogs of the folate cofactor; they oft

Toward Rational Design of Species-Specif

Toward Rational Design of Species-Specific Inhibitors of Pneumocystis carinii Thymidylate Synthase and Toxoplasma gondii Dihydrofolate Reductase-Thymidylate Synthase

✍ KIMBERLY A.W. PEASLEE; AMY C. ANDERSON 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB

Structure-based studies on species-speci

Structure-based studies on species-specific inhibition of thymidylate synthase

✍ M.Paola Costi; Donatella Tondi; Marcella Rinaldi; Daniela Barlocco; Piergiorgio 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 298 KB

ChemInform Abstract: Thymidylate Synthas

ChemInform Abstract: Thymidylate Synthase Inhibition: A Structure-Based Rationale for Drug Design

✍ M. P. COSTI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views