✦ LIBER ✦

Structure and variability of human chromosomes analyzed by recent techniques

✍ Scribed by W. Schnedl

Publisher: Springer
Year: 1978
Tongue: English
Weight: 480 KB
Volume: 41
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00278866

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✦ Synopsis

Besides the AT-specific fluorochromes, GC-specific fluorescent antibiotics are now available for chromosomal analysis. Chromosomal bands represent large accumulation of DNA sequences with similar AT:GC ratio. These uniform differences from the mean AT:GC ratio in the bands can be explained only by at least partial repetition of short DNA sequences in these regions. By comparison of various staining techniques more information also on the constitutive heterochromatin in man becomes available. The human NOR region exhibits a complex organization when studied by various base-specific fluorochromes and silver staining. The DNA-specific fluorochromes are also useful tools in cytophotometric DNA measurements.

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