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Structure and stability of the Boc(D-Pro-L-Pro)2OCH3 Na+ complex: A model of poly(D,L-proline), an alkali ion channel across membranes

✍ Scribed by P. De Santis; A. Scipioni; A. Palleschi; M. Savino

Publisher: Wiley (John Wiley & Sons)
Year: 1989
Tongue: English
Weight: 475 KB
Volume: 28
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360280129

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✦ Synopsis

In order to elucidate the molecular mechanisms of alkali ions conduction of poly(D,L-proline), which shows the typical behavior of an ion channel across membranes, conformations of the tetrmeric derivative Boc(~-Pro-bPro),OCH, in solution, in the presence of the Na+ ion, were investigated by CD and nmr spectroscopy. Both theoretical and experimental data indicate the formation in solution of a monomeric complex between the tetramer, in the all-trans conformation, and the cation. The results allow to confirm the channel model, previously proposed on the phenomenological behavior of poly(D,L-proline) in membranes.

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Structural investigation of poly-L,D-proline, a synthetic ion channel across bilayer membranes: Crystal structure and molecular conformation of two tetra-D,L-proline derivatives

✍ M. Colapietro; P. De Santis; A. Palleschi; R. Spagna 📂 Article 📅 1986 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 494 KB 👁 1 views

The crystal structures and molecular conformations of two tetraproline derivatives with alternating configurations Boc(D-Pro,L-Pro),OH and Boc(D-Pro,L-Pro),OCH,~ are investigated in connection with the ability of the homologous polymer to selectively increase (as an ion channel) the ion permeability