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Structural investigation of poly-L,D-proline, a synthetic ion channel across bilayer membranes: Crystal structure and molecular conformation of two tetra-D,L-proline derivatives

✍ Scribed by M. Colapietro; P. De Santis; A. Palleschi; R. Spagna

Publisher: Wiley (John Wiley & Sons)
Year: 1986
Tongue: English
Weight: 494 KB
Volume: 25
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360251202

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✦ Synopsis

The crystal structures and molecular conformations of two tetraproline derivatives with alternating configurations Boc(D-Pro,L-Pro),OH and Boc(D-Pro,L-Pro),OCH,~ are investigated in connection with the ability of the homologous polymer to selectively increase (as an ion channel) the ion permeability across bilayer membranes. Both tetramers are characterized by the cish-ans alternating conformation of the peptide bonds, which formally transforms in a turn of the pOly-D,L-prOline channel after a czstruns change of the central peptide residue.

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Structure and stability of the Boc(D-Pro-L-Pro)2OCH3 Na+ complex: A model of poly(D,L-proline), an alkali ion channel across membranes

✍ P. De Santis; A. Scipioni; A. Palleschi; M. Savino 📂 Article 📅 1989 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 475 KB 👁 2 views

In order to elucidate the molecular mechanisms of alkali ions conduction of poly(D,L-proline), which shows the typical behavior of an ion channel across membranes, conformations of the tetrmeric derivative Boc(~-Pro-bPro),OCH, in solution, in the presence of the Na+ ion, were investigated by CD and