✦ LIBER ✦

Structure and stability of complexes formed by nucleic acids. I. Binding of acridine to DNA

✍ Scribed by D. J. Bleaks; S. S. Danyluk

Publisher: Wiley (John Wiley & Sons)
Year: 1967
Tongue: English
Weight: 839 KB
Volume: 5
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.1967.360050608

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✦ Synopsis

Synopsis

Nuclear magnetic resoiiaiice spectra of acridine have been measured in aqueous methanol solutions over a wide concentration range in the presence and absence of dissolved UNA. In solutions containing DNA the acridiiie spectra show a marked line broadening and intensity decrease at temperatures lower than 50°C. These line-shape changes can be associated with two types of binding iriteract,ions: ( 1 ) a tight, irrotational binding of the acridine a t low acridine:phosphate ratios and ( 2 ) a weaker, rotat.ionally less restrictive binding a t high acridine concentrations. At temperatures above 50°C. a marked line narrowing is noted for the acridine spect,rum and is at,tribiited to an increase in mobility of the bound acridine as the DNA complex Iindergoes a helixcoil transit ion. A loose association of acridine molecules with the purine and pyrimidine bases in heat-denatured DNA is indicated by chemical shift changes in the acridirie spectriim. The NRIR measiirements also show that the presence of acridiiie in denatured DNA solutions greatly reduces renatiiration of the DNA.

* The general term acridines is used to denote cornpounds with the ring striictiire:

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