Structure and function of the heat-stable enterotoxin receptor/guanylyl cyclase C
β Scribed by Arie B. Vaandrager
- Book ID
- 110327422
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 173 KB
- Volume
- 230
- Category
- Article
- ISSN
- 0300-8177
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π SIMILAR VOLUMES
The heat-stable enterotoxins (ST) are a family of cysteine-rich low-molecular weight peptides produced by pathogenic bacteria, and are one of the major causes of watery diarrhea all over the world. These toxins mediate their action by binding to an intestinal cell surface receptor that is a membrane
## Abstract Guanylyl cyclase C (GCβC), a transmembrane receptor for bacterial heatβstable enterotoxin and the mammalian peptides guanylin and uroguanylin, mediates intestinal ion secretion and affects intestinal cell growth via cyclic GMP signaling. In intestinal tumors, GCβC expression is maintain
The heat-stable enterotoxin STa of E. coli causes diarrhea by binding to and stimulating intestinal membrane-bound guanylyl cyclase, triggering production of cyclic GMP. Agents which stimulate protein kinase C (PKC), including phorbol esters, synergistically enhance STa effects on cGMP and secretion