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Structural features of Escherichia coli heat-stable enterotoxin that activates membrane-associated guanylyl cyclase

✍ Scribed by Sato, T. ;Shimonishi, Y.

Book ID: 110893753
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 292 KB
Volume: 63
Category: Article
ISSN: 1397-002X
DOI: 10.1111/j.1399-3011.2004.00125.x

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## Abstract Guanylyl cyclase C (GC‐C), a transmembrane receptor for bacterial heat‐stable enterotoxin and the mammalian peptides guanylin and uroguanylin, mediates intestinal ion secretion and affects intestinal cell growth via cyclic GMP signaling. In intestinal tumors, GC‐C expression is maintain