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Structure-activity studies of neurotensin on muscular rigidity and tremors induced by 6-hydroxydopamine lesions in the posterolateral hypothalamus of the rat

✍ Scribed by R. Rivest; S. St-Pierre; F.B. Jolicoeur


Book ID
118956396
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
641 KB
Volume
30
Category
Article
ISSN
0028-3908

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In rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigro-striatal pathway, striatal D,-receptor-stimulated c-fos expression and turning behavior are positively modulated by D, receptor stimulation and by blockade of N-methyl-D-aspartate (NMDA) or muscarinic receptors. Combined D1