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Structure-activity relationships of some pyrethroids in rats

✍ Scribed by R. D. Verschoyle; W. N. Aldridge

Publisher: Springer-Verlag
Year: 1980
Tongue: English
Weight: 263 KB
Volume: 45
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00293813

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✦ Synopsis

The intravenous toxicity to the rat of 36 pyrethroids has been examined. With two exceptions they cause either (1) T-syndrome, consisting of aggressive sparring, sensitivity to external stimuli, fine progressing to gross whole body tremor and prostration or (2) CS-syndrome, consisting of pawing and burrowing behaviour, salivation, coarse tremor, progressing to sinuous writhing (choreoathetosis) and clonic seizures. The two exceptions presented a TS-syndrome with salivation associated with the T-syndrome. No clearcut relationship between chemical structure and symptoms of poisoning has emerged through some generalisations are discussed.

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