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Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kB activation

✍ Scribed by Jae-Hwan Kwak; Byung Hak Kim; Jae-Kyung Jung; Youngsoo Kim; Jungsook Cho; Heesoon Lee


Book ID
105674198
Publisher
Springer
Year
2007
Tongue
English
Weight
525 KB
Volume
30
Category
Article
ISSN
0253-6269

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Structure–activity relationship of indol
✍ Jae-Hwan Kwak; Yoseob Kim; Hyunjeong Park; Jae-Yong Jang; Keun Kuk Lee; Wonhui Y 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 251 KB

Chroman derivatives exhibited potent inhibitory activity of NF-kappaB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-kappaB and they were