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Structure-Activity Relationships for a Series of Compounds that Inhibit Aggregation of the Alzheimer's Peptide, A β 42

✍ Scribed by McKoy, Angela F.; Chen, Jermont; Schupbach, Trudi; Hecht, Michael H.


Book ID
121735930
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
300 KB
Volume
84
Category
Article
ISSN
1747-0277

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The major protein constituent of the deposits of Alzheimer's disease is the so-called amyloid ␤-peptide (A␤) which was derived from proteolysis of a large transmembrane amyloid precursor protein. Some physicochemical and biological properties of the A␤(1-42) peptide are described in this paper. Thre