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Structure-activity relationship of gramicidin S analogues on membrane permeability

✍ Scribed by Takashi Katsu; Hideki Kobayashi; Takashi Hirota; Yuzaburo Fujita; Kazuki Sato; Ukon Nagai

Book ID
115728245
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
975 KB
Volume
899
Category
Article
ISSN
0005-2736

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## Abstract Gramicidin S (GS) is a cyclo‐decapeptide antibiotic isolated from __Bacillus brevis__. The structural studies have shown that GS forms a two‐stranded antiparallel β‐sheet imposed by two II′ β‐turns. Despite its wide Gram+ and Gram− antimicrobial spectrum, GS is useless in therapy becaus