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Structure-activity dependency of new bacterial tryptophanyl tRNA synthetase inhibitors

✍ Scribed by David R. Witty; Graham Walker; John H. Bateson; Peter J. O'Hanlon; Robert Cassels

Book ID: 103983452
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 318 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00237-5

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✦ Synopsis

Analogues of the aminoacyl tRNA synthetase inhibitor, indolmycin, have been synthesised in which the side chain methyl group is replaced by a wide range of substituents. Their antibacterial and enzyme inhibitory potency is related to steric properties and conformational preferences.

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