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Structure-action relationship of β-carbolines as monoamine oxidase inhibitors

✍ Scribed by William M. McIsaac; Vicente Estevez

Book ID
115769235
Publisher
Elsevier Science
Year
1966
Tongue
English
Weight
228 KB
Volume
15
Category
Article
ISSN
0006-2952

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✍ Beng T. Ho; William M. McIsaac; L. Wayne Tansey; K. E. Walker 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB

A series of 9-alkyl aromatic 8-carbolines was synthesized and evaluated as inhibitors of mitrochondrial monoamine oxidase. The possible existence of a hydrophobic or hydrophilic region on the enzyme was explored. Substitution of an electron-withdrawing group such as acetyl on N-9 position reduced t