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Structural studies on proteoglycan catabolism in rabbit articular cartilage explant cultures

✍ Scribed by John D. Sandy; Carl R. Flannery; Anna H.K. Plaas

Book ID
119120616
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
521 KB
Volume
931
Category
Article
ISSN
0167-4889

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## Objective: The catabolism of aggrecan and loss of aggrecan fragments from articular cartilage is a key event in the pathogenesis of arthritic diseases such as osteoarthritis. the catabolism of aggrecan is mediated by the specific proteolytic activity termed aggrecanase. the aim of this study was