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Catabolism of Aggrecan by Explant Cultures of Human Articular Cartilage in the Presence of Retinoic Acid

โœ Scribed by M.Z. Ilic; M.T. Mok; O.D. Williamson; M.A. Campbell; C.E. Hughes; C.J. Handley

Book ID
115565741
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
907 KB
Volume
322
Category
Article
ISSN
0003-9861

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## Objective: The catabolism of aggrecan and loss of aggrecan fragments from articular cartilage is a key event in the pathogenesis of arthritic diseases such as osteoarthritis. the catabolism of aggrecan is mediated by the specific proteolytic activity termed aggrecanase. the aim of this study was