Structural studies of breaks in the type IV collagen triple helix
β Scribed by A. Mohs; C. Strafaci; Y. Li; J. Baum; B. Brodsky
- Book ID
- 116729562
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 58 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0945-053X
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Kniest dysplasia is a moderately severe type II collagenopathy, characterized by short trunk and limbs, kyphoscoliosis, midface hypoplasia, severe myopia, and hearing loss. Mutations in the gene that encodes type II collagen (COL2A1), the predominant protein of cartilage, have been identified in a n
## Abstract Helix probability profiles are calculated for collagen models that take into account specific sequence and unwinding from the ends, by internal loops and by chain dissociation, using parameters from a previous study and the technique of the previous paper.^2^ An analysis is made of the