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Structural stabilization of botulinum neurotoxins by tyrosine phosphorylation

✍ Scribed by José A Encinar; Asia Fernández; José A Ferragut; José M González-Ros; Bibhuti R DasGupta; Mauricio Montal; Antonio Ferrer-Montiel

Book ID
117109238
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
218 KB
Volume
429
Category
Article
ISSN
0014-5793

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Structure and enzymatic activity of botu
Structure and enzymatic activity of botulinum neurotoxins
✍ Subramanyam Swaminathan; Subramanian Eswaramoorthy; Desigan Kumaran 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB

The structure of botulinum neurotoxin type B (BoNT/B) is analyzed, and it is demonstrated that the carbonyl oxygen of the scissile bond comes close to the zinc ion to form a Michaelis complex. The hydrated carbonyl is activated by the nucleophilic water, which moves closer to Glu 230 to form hydroge