Structural Stability Effects on Adsorption of Bacteriophage T4 Lysozyme to Colloidal Silica
โ Scribed by Minghua Tian; Woo-Kul Lee; Michelle K. Bothwell; Joseph McGuire
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 200 KB
- Volume
- 200
- Category
- Article
- ISSN
- 0021-9797
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Maintaining a specific molecular conformation is essential for the proper functioning of an enzyme. A substantial loss of catalytic activity can occur from the displacement caused by even a single amino acid substitution. Activity may also be lost as an enzyme undergoes a conformational change durin
Enzyme structure and function depend to some extent on enzyme net charge and charge location. Altering the charge of even a single residue may affect the interaction between enzyme and substrate such that all catalytic activity is lost. In this study we investigated the effect of net charge and char
## NOTE Adsorption Kinetics of Wild Type and Two Synthetic Stability Mutants of T4 Phage Lysozyme at Silanized Silica Surfaces protein than the wild type (12). A mutant with tryptophan substituted for isoleucine at the same position (I3W) was selected as it is one of the least The adsorption kinet