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Structural requirements of a chiral ligand for the catalytic asymmetric addition of thiophenol to α,β-unsaturated esters

✍ Scribed by Kiyoshi Tomioka; Manabu Okuda; Katsumi Nishimura; Shino Manabe; Motomu Kanai; Yasuo Nagaoka; Kenji Koga


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
210 KB
Volume
39
Category
Article
ISSN
0040-4039

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✍ Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli; Claudia Tomasini 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 720 KB

The synthesis of enantiomerically enriched a-amino acids is described, by means of the diastereoselective conjugate addition of Grignard reagent to (S)-2-acetamidoacrylic ethoxycarbonylphenyl-methyl ester 1 and its N-Boo derivative 5 in the presence of Lewis acids. The addition of magnesium organocu