Asymmetric induction in the addition of thioacetic S-acid to α,β-unsaturated esters
✍ Scribed by Jacek K. Gawroński; Krystyna Gawrońska; Halina Kolbon; Hans Wynberg
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 500 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0165-0513
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The addition of&-nucleophiles to unsaturated substrates has recently drawn both theoretical1 and experimental attention. 2 In this report we present data pertaining to the addition ofd-nucleophiles to Cr,$ -unsaturated esters, in particular ethyl cinnamate. We 'lWe h ave also obtained oils having h
The synthesis of enantiomerically enriched a-amino acids is described, by means of the diastereoselective conjugate addition of Grignard reagent to (S)-2-acetamidoacrylic ethoxycarbonylphenyl-methyl ester 1 and its N-Boo derivative 5 in the presence of Lewis acids. The addition of magnesium organocu