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Structural requirements for the binding of ethidium to nucleic acids

โœ Scribed by M.J. Waring


Book ID
115742419
Publisher
Elsevier Science
Year
1966
Weight
633 KB
Volume
114
Category
Article
ISSN
0005-2787

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๐Ÿ“œ SIMILAR VOLUMES


Ethidium bromideโ€“dinucleotide complexes.
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## Abstract The solution complexes of ethidium bromide with nine different deoxydinucleotides and the four selfโ€complementary ribodinucleoside monophosphates as well as mixtures of complementary and noncomplementary deoxydinucleotides were studied as models for the binding of the drug to DNA and RN

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A dimeric derivative of ethidium is used for fluorimetric assay of nucleic acids. Due to the very high binding affinity of this derivative for DNA and RNA, a significant increase of sensitivity of the ethidium fluorimetric technique for nucleic acids determination is obtained. Using a commercially a