Structural requirements for the binding of ethidium to nucleic acids
โ Scribed by M.J. Waring
- Book ID
- 115742419
- Publisher
- Elsevier Science
- Year
- 1966
- Weight
- 633 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0005-2787
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๐ SIMILAR VOLUMES
## Abstract The solution complexes of ethidium bromide with nine different deoxydinucleotides and the four selfโcomplementary ribodinucleoside monophosphates as well as mixtures of complementary and noncomplementary deoxydinucleotides were studied as models for the binding of the drug to DNA and RN
A dimeric derivative of ethidium is used for fluorimetric assay of nucleic acids. Due to the very high binding affinity of this derivative for DNA and RNA, a significant increase of sensitivity of the ethidium fluorimetric technique for nucleic acids determination is obtained. Using a commercially a