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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

✍ Scribed by Hale, Jeffrey J.; Mills, Sander G.; MacCoss, Malcolm; Finke, Paul E.; Cascieri, Margaret A.; Sadowski, Sharon; Ber, Elzbieta; Chicchi, Gary G.; Kurtz, Marc; Metzger, Joseph; Eiermann, George; Tsou, Nancy N.; Tattersall, F. David; Rupniak, Nadia M. J.; Williams, Angela R.; Rycroft, Wayne; Hargreaves, Richard; MacIntyre, D. Euan

Book ID: 120077266
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 189 KB
Volume: 41
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm980299k

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