✦ LIBER ✦

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5( S )-Amino-4( S )-hydroxy-8-phenyl-octanecarboxamides: The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

✍ Scribed by Maibaum, Jürgen; Stutz, Stefan; Göschke, Richard; Rigollier, Pascal; Yamaguchi, Yasuchika; Cumin, Frédéric; Rahuel, Joseph; Baum, Hans-Peter; Cohen, Nissim-Claude; Schnell, Christian R.; Fuhrer, Walter; Gruetter, Markus G.; Schilling, Walter; Wood, Jeanette M.

Book ID: 124077613
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 371 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm070316i

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Novel 2,7-Dialkyl-Substituted 5( S )-Ami

Novel 2,7-Dialkyl-Substituted 5( S )-Amino-4( S )-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin

✍ Göschke, Richard; Stutz, Stefan; Rasetti, Vittorio; Cohen, Nissim-Claude; Rahuel 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 434 KB

ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of Novel 2,7-Dialkyl Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro Potent Peptidomimetic Inhibitors of Human Renin.

✍ R. GOESCHKE; N. C. COHEN; J. M. WOOD; J. MAIBAUM 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Design and Synthesis of Novel 2,7-Dialkyl Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro Potent Peptidomimetic Inhibitors of Human Renin. -Novel renin inhibitors (I), which are created on a topographical design approach, are prepared by literature methods. (I) have IC 50