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Novel 2,7-Dialkyl-Substituted 5( S )-Amino-4( S )-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin

✍ Scribed by Göschke, Richard; Stutz, Stefan; Rasetti, Vittorio; Cohen, Nissim-Claude; Rahuel, Joseph; Rigollier, Pascal; Baum, Hans-Peter; Forgiarini, Peter; Schnell, Christian R.; Wagner, Trixie; Gruetter, Markus G.; Fuhrer, Walter; Schilling, Walter; Cumin, Frédéric; Wood, Jeanette M.; Maibaum, Jürgen


Book ID
126801628
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
434 KB
Volume
50
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Design and Synthesi
✍ R. GOESCHKE; N. C. COHEN; J. M. WOOD; J. MAIBAUM 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Design and Synthesis of Novel 2,7-Dialkyl Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro Potent Peptidomimetic Inhibitors of Human Renin. -Novel renin inhibitors (I), which are created on a topographical design approach, are prepared by literature methods. (I) have IC 50