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Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase

โœ Scribed by Yuan He; Carlos Martinez-Fleites; Abigail Bubb; Tracey M. Gloster; Gideon J. Davies


Book ID
108080597
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
977 KB
Volume
344
Category
Article
ISSN
0008-6215

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Recent Insights into Inhibition, Structu
โœ Tom D. Heightman; Andrea T. Vasella ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 744 KB

Not "from above", but "from the side": Configuration-retaining ฮฒ-glycosidases protonate their substrate either anti or syn to the endocyclic C1-O bond as the first step in the enzymic cleavage of the glycosidic bond (see schematic drawing). Insights into the mechanism of action of glycosidases have