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Structural homologies of component C5 of human complement with components C3 and C4 by neutron scattering

✍ Scribed by Perkins, Stephen J.; Smith, Kathryn F.; Nealis, Adam S.; Lachmann, Peter J.; Harrison, Richard A.


Book ID
126293330
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
769 KB
Volume
29
Category
Article
ISSN
0006-2960

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The effect of cadralazine and its active metabolite CGP 22639 on the covalent binding reaction of C4 and C3 has been studied. Trypsin-Sepharose was used to activate radio-labelled C3 and C4 and binding of the radio-labelled protein to the trypsin-Sepharose was measured. Cadralazine inhibited 50% of