Structural features of phenoxycarbonylimino neonicotinoids acting at the insect nicotinic receptor

✍ Scribed by Ikuya Ohno; Motohiro Tomizawa; Nozomi Miyazu; Gohito Kushibiki; Kumiko Noda; Yasunori Hasebe; Kathleen A. Durkin; Taiji Miyake; Shinzo Kagabu

• Book ID: 104004656
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 320 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.07.049

✦ Synopsis

Substituted-phenoxycarbonylimino neonicotinoid ligands with an electron-donating group showed significantly higher affinity to the insect nicotinic receptor relative to that of the analogue with an electron-withdrawing substituent, thereby establishing in silico binding site interaction model featuring that the phenoxy ring of neonicotinoids and the receptor loop D tryptophan indole plane form a faceto-edge aromatic interaction.