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Structural features important for the biological activity of the potassium channel blocking dendrotoxins

โœ Scribed by Michelle Hollecker; David L. Marshall; Alan L. Harvey


Book ID
117959935
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
1008 KB
Volume
110
Category
Article
ISSN
0007-1188

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โœ Etsuko Katoh; Hideki Nishio; Tatsuya Inui; Yuji Nishiuchi; Terutoshi Kimura; Shu ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 389 KB ๐Ÿ‘ 2 views

A topochemical model to explain the biological activity of dendrotoxin-I (DTX-I), a potent blocker for potassium channels, was developed by searching common spatial arrangements of functionally important residues between DTX-I, alpha-dendrotoxin, dendrotoxin-K, BgK, ShK, and charybdotoxin. The first