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Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin

โœ Scribed by U. Weller; U. Bernhardt; D. Siemen; F. Dreyer; W. Vogel; E. Habermann

Book ID
112342946
Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
752 KB
Volume
330
Category
Article
ISSN
0028-1298

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A topochemical model to explain the biological activity of dendrotoxin-I (DTX-I), a potent blocker for potassium channels, was developed by searching common spatial arrangements of functionally important residues between DTX-I, alpha-dendrotoxin, dendrotoxin-K, BgK, ShK, and charybdotoxin. The first