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Structural Evidence for α-Synuclein Fibrils Using in Situ Atomic Force Microscopy

✍ Scribed by Feng ZHANG; Li-Na JI; Lin TANG; Jun HU; Hong-Yu HU; Hong-Jie XU; Jian-Hua HE


Book ID
111357564
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
807 KB
Volume
37
Category
Article
ISSN
1672-9145

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In this report, we applied in situ atomic force microscopy (AFM) to study the dynamic process of disassembly-assembly of a-synuclein (a-Syn) fibrils in different solutions. Most of the mica-adsorbed a-Syn fibrils disassemble into small particles step-by-step on the mica surface in diluted solutions,