Structural elucidation of two major metabolites of crisnatol in the rat by NMR and mass spectrometry

✍ Scribed by John P. Shockcor; Dipak K. Patel; Robert L. Johnson; Lester C. E. Taylor; Pisal Chandrasurin

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 556 KB
• Volume: 30
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1260300303

✦ Synopsis

Abstract

NMR and mass spectral data are presented in support of the structures of two metabolites of crisnatol, 2‐[(6‐chrysenylmethyl)amino]‐2‐methylpropane‐1,3‐diol, a novel DNA intercalator currently undergoing Phase II clinical trials as an anticancer agent. Elucidation of the structures of the major rat urinary metabolite as trans‐1,2‐dihydro‐1,2‐dihydroxycrisnatol, and the major rat fecal metabolite as 1‐hydroxycrisnatol, using 2D NMR techniques are described.