Structural effects on the antitumour activity of a series of di(4-substituted phenyl)tin dichloride complexes with nitrogen-donor ligands

✍ Scribed by Brain N Biddle; John S Gray

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 490 KB
• Volume: 3
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/aoc.590030610

✦ Synopsis

Investigation of the antitumour activity of a series of diorganotin dichloride complexes (4-ZCsH4) zSnClz. b, where Z = OMe, Me, F, C1, and CF3 and Lz = 2,2'-bipyridyl (bipy), 1 ,lo-phenanthroline (phen) and 2-aminomethylpyridine (amp) is reported. A number of these complexes are shown to exhibit reproducible activity in vivo towards P388 lymphocytic leukaemia in mice. 'H NMR data are reported for an extended series of (4-ZCa4) 4Sn and the parent dichlorides (4-ZCsH4)zSnC1z of the above-mentioned complexes. A correlation is reported between Hammett substituent constants and 'PI chemical shift data. Attempts are made to relate the antitumour activity of the complexes to various structural factors. The dependence of antitumour activity on the electronic effect of group Z and the nature of the ligand Lz is demonstrated.