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Structural effect of P278A mutation conferring breast cancer susceptibility in the p53 DNA-binding core domain

โœ Scribed by Y Suneetha, C Kumaraswamy Naidu


Book ID
120684724
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
77 KB
Volume
6
Category
Article
ISSN
1753-6561

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The tumor suppresser protein p53 has been called the "guardian of the genome." DNA damage induces p53 to either halt the cell cycle, allowing for repair, or initiate apoptosis. P53 is mutated in over 50% of human tumors and it has been proposed that many tumorigenic mutations are deleterious to p53