Structural effect of P278A mutation conferring breast cancer susceptibility in the p53 DNA-binding core domain
โ Scribed by Y Suneetha, C Kumaraswamy Naidu
- Book ID
- 120684724
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 77 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1753-6561
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## Abstract Tumor suppressor protein p53 becomes inactive due to mutation on its DNA binding core domain leading to misbehavior of this protein and preventing its interaction with DNA. In the present study, changes of the protein conformation by five hot spot mutations of T-p53C were assessed preve
The tumor suppresser protein p53 has been called the "guardian of the genome." DNA damage induces p53 to either halt the cell cycle, allowing for repair, or initiate apoptosis. P53 is mutated in over 50% of human tumors and it has been proposed that many tumorigenic mutations are deleterious to p53