Proliferation of smooth muscle cells from the pulmonary arteries and aortas of fetal calves is inhibited by heparin in vitro. This effect is reversible and dose dependent. Comparisons with effects of other polysaccharides indicate that only extensively sulfated polysaccharides inhibit proliferation
Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells
β Scribed by John J. Castellot Jr.; Morris J. Karnovsky; David L. Beeler; Robert D. Rosenberg
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 716 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0021-9541
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## Abstract Heparin is a well established growth inhibitor of arterial smooth muscle cells (SMCs) both in animal models and in vitro. Even though the cellular mechanisms involved in the antiβproliferative properties of heparin are being resolved, the structural requirements for the biological effec
Heparin and heparan are potent inhibitors of vascular smooth muscle cell (VSMC) proliferation. To investigate the mechanisms by which heparin suppresses growth factor stimulated mitogenesis, the present experiments investigated the effects of heparin on platelet-derived growth factor (PDGF) stimulat