Inhibition of vascular smooth muscle cell migration by heparin-like glycosaminoglycans
β Scribed by Richard A. Majack; Alexander W. Clowes
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 476 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0021-9541
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π SIMILAR VOLUMES
Heparin and heparan are potent inhibitors of vascular smooth muscle cell (VSMC) proliferation. To investigate the mechanisms by which heparin suppresses growth factor stimulated mitogenesis, the present experiments investigated the effects of heparin on platelet-derived growth factor (PDGF) stimulat
## Abstract Previous work from our laboratory has shown that heparin inhibits the proliferation of vascular smooth muscle cells in vivo and in vitro. The mechanism of action of this glycosaminoglycan is unknown. In this communication, we have examined the antiproliferative effect of heparin on smoo
## Abstract Heparin is a well established growth inhibitor of arterial smooth muscle cells (SMCs) both in animal models and in vitro. Even though the cellular mechanisms involved in the antiβproliferative properties of heparin are being resolved, the structural requirements for the biological effec