Structural Characterization of LNA and α-L-LNA Hybridized to RNA
✍ Scribed by Michael Petersen; Jakob T. Nielsen; Kent Bondensgaard; Jesper Wengel; Jens Peter Jacobsen
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 54 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
Alpha-LNA is presented as a stereoisomer of LNA (locked nucleic acid) with alpha-D-configuration. Three different approaches towards the thymine alpha-LNA monomer as well as the 5-methylcytosine alpha-LNA monomer are presented. Different alpha-LNA sequences have been synthesised and their hybridisat
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract We describe the synthesis and binding properties of oligonucleotides that contain one or more 2′‐fluoro‐α‐L‐RNA thymine monomer(s). Incorporation of 2′‐fluoro‐α‐L‐RNA thymine into oligodeoxynucleotides decreased thermal binding stability slightly upon hybridization with complementary DN