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Structural basis of ligand recognition in 5-HT3 receptors

✍ Scribed by Kesters, Divya; Thompson, Andrew J; Brams, Marijke; van Elk, René; Spurny, Radovan; Geitmann, Matthis; Villalgordo, Jose M; Guskov, Albert; Helena Danielson, U; Lummis, Sarah C R; Smit, August B; Ulens, Chris


Book ID
120071693
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
854 KB
Volume
14
Category
Article
ISSN
1469-221X

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ChemInform Abstract: A New 5-HT3 Recepto
✍ M. YAMADA; Y. SATO; K. KOBAYASHI; F. KONNO; T. SONEDA; T. WATANABE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views

Several substituted 2-pyridazinyl benzoxazole derivatives (VII), (VIII) and (IX) are prepared and evaluated for their utility as 5-HT 3 receptor agonists. A detailed structure-activity relationship study is presented. The most promising results are obtained for the derivatives (VIIa), (VIId) and (VI