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Structural basis of cyclin-dependent kinase activation by phosphorylation

✍ Scribed by Russo, Alicia A. ;Jeffrey, Philip D. ;Pavletich, Nikola P.


Book ID
109965057
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
665 KB
Volume
3
Category
Article
ISSN
1545-9993

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## Abstract A cyclin‐dependent kinase, Cdk2, catalyzes the transfer of the γ‐phosphate from ATP to a threonine or serine residue of its polypeptide substrates. Here, we investigate aspects of the reaction mechanism of Cdk2 by gas‐phase density functional calculations, classical molecular dynamics,