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Structural Basis for Topoisomerase I Inhibition by Nucleoside Analogues

✍ Scribed by William H. Gmeiner; Shuyuan Yu; Richard T. Pon; Philippe Pourquier; Yves Pommier


Publisher
John Wiley and Sons
Year
2004
Weight
70 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract An oligonucleotide analogue containing a novel heterocyclic analogue, the guanidinium G‐clamp, was designed to allow formation of five H‐bonds to guanosine. The guanidinium group was introduced postsynthetically by treatment of the deprotected oligonucleotide containing a free amino gro