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ChemInform Abstract: Structure—Activity Relationships for Analogues of the Phenazine-Based Dual Topoisomerase I/II Inhibitor XR11576.

✍ Scribed by Shouming Wang; Warren Miller; John Milton; Nigel Vicker; Alistair Stewart; Peter Charlton; Prakash Mistry; David Hardick; William A. Denny

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
33
Category
Article
ISSN
0931-7597

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## Abstract A variety of (het)aryl‐substituted benzoquinoline derivatives (III) (24 examples) is designed, synthesized and evaluated for their topoisomerase inhibitory activities and their cytotoxicity against several human cancer cell lines.