𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

✍ Scribed by Fesik, Stephen W.; Liu, Zhihong; Sun, Chaohong; Olejniczak, Edward T.; Meadows, Robert P.; Betz, Stephen F.; Oost, Thorsten; Herrmann, Julia; Wu, Joe C.


Book ID
109773004
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
375 KB
Volume
408
Category
Article
ISSN
0028-0836

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Structural basis for the binding of high
✍ John S. McMurray πŸ“‚ Article πŸ“… 2007 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 451 KB

## Abstract Signal transducer and activator of transcription 3 (Stat3) is constitutively active in a number of cancers where it participates in aberrant transcription of prosurvival, cell cycling, and angiogenesis genes. Since Stat3 initiates its signaling activity through binding of its SH2 domain

The structure of the BIR3 domain of cIAP
✍ Kulathila, Raviraj ;Vash, Brian ;Sage, David ;Cornell-Kennon, Susan ;Wright, Kir πŸ“‚ Article πŸ“… 2008 πŸ› International Union of Crystallography 🌐 English βš– 989 KB

The inhibitor of apoptosis protein (IAP) family of molecules inhibit apoptosis through the suppression of caspase activity. It is known that the XIAP protein regulates both caspase-3 and caspase-9 through direct protein-protein interactions. Specifically, the BIR3 domain of XIAP binds to caspase-9 v