𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structural Aspects of Bile Salt-Lecithin Mixed Micelles

✍ Scribed by Karl Müller

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
466 KB
Volume
4
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

Mixed micells formed by the major constituents of native bile, i.e., bile salts and lecithin, were studied by X-ray scattering differential scanning calorimetry and electron spin resonance spectroscopy. The aim of this study was to find differences in micellar structure and thermodynamic properties which might explain the different abilities of various biles to keep cholesterol in solution at comparable degrees of oversaturation. The data indicate not only that different types of micelles exist but also that different types of complex bile salt/phospholipid arrangements exist within the micelles. It is speculated that the stabilizing and destabilizing factors found by other authors influence the balance between the different micellar structures and thereby the cholesterol solubilization power of bile.

📜 SIMILAR VOLUMES

Aqueous Bile Salt-Lecithin-Cholesterol S
Aqueous Bile Salt-Lecithin-Cholesterol Systems: Equilibrium Aspects
✍ Martin C. Carey 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB

Cholesterol is solubilized by bile salt and bile salt-lecithin micelles without appreciable alteration in preexisting micellar size or structure. In dilute (-3 gm per dl) model bile, but not in concentrated (-10 gm per dl) systems, supramicellar concentrations of cholesterol are also solubilized in

Bile Salt Structure and Phase Equilibria
Bile Salt Structure and Phase Equilibria in Aqueous Bile Salt and Bile Salt-Lecithin Systems
✍ Martin C. Carey 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 577 KB

The hydrophilic-hydrophobic balance of bile salt monomers can be readily quantified by their elution sequence during reverse-phase high-performance liquid chromatography. Such studies have demonstrated that subtle variations in bile salt structure have profound effects on the hydrophilic-hydrophobic

Kinetics and Thermodynamics of Dissoluti
Kinetics and Thermodynamics of Dissolution of Lecithin by Bile Salts
✍ Siegfried Lindenbaum; Natarajan Rajagopalan 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 573 KB

The kinetics of dissolution of dispersions of egg phosphatidylcholine (lecithin) by bile salts WBS studied by observing the decrease in turbidity as mixed micelles of lecithin and bile salts were formed. The rate of dissolution of lecithin corresponding to formation of mixed micelles was studied in

Examination of the solubilization of dru
Examination of the solubilization of drugs by bile salt micelles
✍ Timothy Scott Wiedmann; Lamya Kamel 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 164 KB

The purpose of this review is to provide a critical examination of the reported solubilization of drugs by bile salt micelles. The underlying premise is that with better information regarding the inherent biological complexity, efforts to predict the oral bioavailability of drug will be enhanced. Th